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#covidcompetent

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that Blood Advances paper aligns with earlier autopsy results, and confirmed

SARS-CoV-2+ megakaryocytes are present in lung and brain autopsy tissues from deceased donors who had COVID-19

But heck! We already knew MKs were long-term impacted. This from 2024 ashpublications.org/bloodadvan - though in mice gives what I guess should be an obvious outcome, since the immune system isn't open-loop:

Megakaryocytes (MKs), integral to platelet production, predominantly reside in the bone marrow. [...] at peak SARS-CoV-2 viremia, when the disease primarily affected the lungs, MKs were not significantly different from those from healthy mice. Conversely, a significant divergence in the MK transcriptome was observed during systemic inflammation, although SARS-CoV-2 RNA was never detected in the BM, and it was no longer detectable in the lungs. Under these conditions, the MK transcriptional landscape was enriched in pathways associated with histone modifications, MK differentiation, NETosis, and autoimmunity

and autoimmunity

The breadcrumbs are everywhere.

fin/🧵

#CovidIsAirborne#SARSCoV2#Covid
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That aligns with results from 2022-2023 like ashpublications.org/bloodadvan which found

Using peripheral blood, we show that megakaryocytes are increased in the systemic circulation in COVID-19

peripheral blood - circulating!!

SARS-CoV-2–containing megakaryocytes are a strong risk factor for mortality and multiorgan injury

2/🧵

American Society of HematologyCirculating SARS-CoV-2+ megakaryocytes are associated with severe viral infection in COVID-19Key Points. To our knowledge, we provide the first evidence implicating SARS-CoV-2+ peripheral blood megakaryocytes in severe disease.Circulating megakaryo
#CovidIsAirborne#SARSCoV2#Covid
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So. How about this careful result demonstrating viral replication inside megakaryocyte immune cells?

transmission electron microscopy pointed to the presence of viral particles inside bone marrow MK. Immunolabeling confirmed the presence of two SARS-CoV-2 proteins, spike and Orf3a, as well as double-stranded RNA suggesting a potential viral replication cycle.

Note this study is from last month, but it's from hospitalized 2020-2021 patient data. It's existence proof, not population statistics.

That said:

bone marrow MK infection is not a strict determinant of mortality. However, all survivors experienced post-acute sequelae SARS-CoV-2 condition (PASC) diagnosed during post-intensive care follow-up

short 🧵

#CovidIsAirborne#SARSCoV2#COVID
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@themaskerscomic this is really remarkably solid data

The cohort included 297,920 SARS-CoV-2-positive individuals and 915,402 SARS-CoV-2-negative controls. Every individual had at least a six-month follow-up after cohort entry

With a range of risk ratios from roughly +25% to +200%! That's up to triple the risk!

children and adolescents [...] infected with SARS-CoV-2 exhibited increased risks for a range of post-acute cardiovascular outcomes, with RR [risk ratio] between 1.26 and 2.92

and things have not gotten better with newer variants:

similar cardiovascular outcomes in children infected with the Delta and Omicron variants

nature.com/articles/s41467-025 also via @TRyanGregory

NatureCardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records - Nature CommunicationsPost-acute sequelae of SARS-CoV-2 infection affecting the cardiovascular system have been reported, but evidence in young people is limited. Here, the authors quantify the incidence of a range of outcomes in children and adolescents using electronic health records from the United States.
#COVIDIsNotOver#COVID#SARSCoV2
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Some highlights from @ducky 's weekly roundup at covidbc.webfoot.com/2025/03/28

SARS-CoV-2 can interact with / activate the CD147 receptor to get into lymphocytes (T-cells and B-cells). (sciencedirect.com/science/arti)

women are 13.4 times more likely to get Long COVID if they are 🤰pregnant than if they are 🚫🤰not, with the danger highest if they catch COVID-19 in the third trimester. (sciencedirect.com/science/arti)

the rate of cases of postural orthostatic tachycardia syndrome (POTS) has gone up more than fourteen times compared to pre-pandemic (academic.oup.com/ehjqcco/advan)

covidbc.webfoot.com2025-03-28 General – Pandemics in British Columbia
#CovidCompetent#AirborneAware#CovidIsNotOver
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Most interesting detail: "we detected the virus passing from one sinus at the peak of infection to the other a few days later"

Model animals: "cynomolgus macaques"

They also evaluated "two convalescent animals [...] exposed to the SARS-CoV-2 Delta variant three months prior" and found "no major uptake by the nasal cavity" but "detection of the PET signal for SARS-CoV-2 spike antigen up to three months post initial infection in the lungs and brains"

"local accumulation [...] in areas of the brain [...] consistent with previous findings of neuroinflammation in humans infected with SARS-CoV-2 and in rhesus macaques up to six weeks after SARS-CoV-2 infection. The localized crossing of the blood-brain barrier (BBB) by the radiotracer in convalescent animals can be explained by thrombo-inflammation previously reported in patients with active long-COVID."

nature.com/articles/s41467-025

h/t @EricCarroll

NatureWhole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates - Nature CommunicationsThere are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain 3 months after infection.
#SARSCoV2#COVID19#COVID
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Hey men who enjoy sex! MASK UP TO KEEP IT UP! :mastorespirator: 🍆

If taking a soccer ball ⚽ to the crotch had 1/5 odds of long term erectile dysfunction (ED) would you wear a cup when you play soccer?

nature.com/articles/s41598-025

20% of men in this study got NEW ED - and only 1/4 "got their mojo back" after two years.

NaturePrevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients - Scientific ReportsCoronavirus disease-2019 (COVID-19) is associated with a wide range of post-acute sequelae. The prevalence of erectile dysfunction (ED) that developed after COVID-19 and the associated underlying factors were analyzed based on a questionnaire survey, COVID-19 Recovery Study II in Japan. A case–control study was conducted with those with or without ED one and two years hospitalized with COVID-19 between March and September 2021. Six hundred and nine Japanese men, with a median age of 48 years, were analyzed. During the study period, 116 subjects (19.0%) had erectile dysfunction. The patients with ED responded with less subjective awareness of recovery and high breathless and fatigue scores compared to those without ED. The patients with ED also showed higher Hospital Anxiety and Depression Scale-D (depression) and the EuroQol 5-dimensions 5-level scores for pain/discomfort and anxiety/depression scores compared before COVID-19 infection. Sleep disturbance was suggested to be associated with erectile dysfunction using an exploratory clustering analysis in the one-year survey. There were no associations of COVID-19 severity, reinfection, vaccination frequency, antiviral treatment for COVID-19 with the presence of erectile dysfunction. It was considered that mental support for the subject with erectile dysfunction as a long-COVID symptom is warranted.
#MaskUpToKeepItUp#MaskUp#reproductiveHealth
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The person - the man - who spends the most on anti-aging in the world, whose physiology is the most measured in the world?

Lost 15% of lung capacity to "mild" acute COVID-19.

donotpanic.news/p/the-billiona

To be clear, 15% is not "you take an extra 6th breath for every 5." It is worse in ways that you can investigate for yourself. It is Not Good.

¡Do Not Panic! · The Billionaire Who Wants To Live Forever Has Long CovidBy Nate Bear
#CovidIsNotOver#COVID19#COVID
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If we were to see immune damage manifesting at a population level, it would look like what we’re seeing today: big waves of common illnesses. Unusual spikes of uncommon illnesses. Course reversal for previously declining and eliminated illnesses. An unexplained, global wave of sickness.

How much more denial can the bodies of our children take? Are we going to force them to find out?

lots of citations demonstrating that damage and more at thegauntlet.news/p/kids-keep-g

The Gauntlet · Kids keep getting sicker as evidence for COVID immune damage buildsBy Julia Doubleday
#AirborneAware#CovidCompetent#LongCOVID
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@Westcoastmaven I hear you, and regret to inform you that neither the official narrative nor the corporate media narrative are aligned with scientific results. The risk of acute death was always low in relatively healthy people. The risk of long term damage per single infection was and remains high, with Statistics Canada estimating that half of people don't fully recover from Long COVID, and that more than 1/3 of people experience Long COVID symptoms by their 3rd COVID-19 infection.

And that 1/3 risk of Long COVID symptoms by a third infection IS if the person is vaccinated.

And numerically, cases are not low right now:

"Canadian COVID Forecast Mar 1-14, 2025

About 1 in every 52 people infected

Compared to lowest point of pandemic in Canada:
-Infections ~14X higher
-Long COVID ~13X higher
-Hospitalizations ~12X higher
-Deaths ~11X higher"

from fed.brid.gy/r/https://bsky.app who are still doing COVID-19 modelling at UofT

Bluesky Social · Tara Moriarty (@moriartylab.bsky.social)Canadian COVID Forecast Mar 1-14, 2025 CANADA VERY HIGH (no change) About 1 in every 52 people infected Compared to lowest point of pandemic in Canada: -Infections ~14X higher -Long COVID ~13X higher -Hospitalizations ~12X higher -Deaths ~11X higher
#COVID#CovidIsNotOver#AirborneAware
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"We know that infection and reinfection, even when mild, is linked to cell and organ damage that may harm their future health. More needs to be done to protect our children, and the first step is ensuring that our schools are safe"

"The briefing also says Long Covid can also lead to a 'substantially increased' risk of sudden death and 'silent' damage to cells and organs which can lead to later illness.

"Certainly the silent organ damage is a real problem, we think, for future development of disease."

rnz.co.nz/news/national/543885

RNZ · Long Covid warning: 'Silent organ damage is a real problem'By RNZ News
#AirborneAware#CovidCompetent#COVIDIsNotOver
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@augieray @elliek I think Ellie is in Canada

we have slower but cleaned results from:
@MoriartyLab at covid19resources.ca/covid-haza

we have @ratnegative posting wastewater data, with some careful hand cleaning to remove artefacts

we have lots of bots like @wastewater @covid19ab_wastewater @OntarioWasteWater_GTA and more - you can search zeroes.ca for "wastewater bot" and click on "Profiles", I'm not sure if there's a graphic map or a list of known wastewater bots in Canada, but now I kinda want to compile one.

COVID-19 Resources CanadaCanadian COVID-19 Hazard Index
#CovidCompetent#AirborneAware#COVIDIsNotOver
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Learn from history. HISTORY INCLUDES THE PAST FIVE YEARS.

Statistics Canada is not falsifying huge datasets.

www150.statcan.gc.ca/n1/daily-

The Tyee is not falsifying long form reporting.

thetyee.ca/Analysis/2024/07/02

McMaster researchers are chasing health, not grants.

healthsci.mcmaster.ca/long-cov (though "can last months" should read "can last months, or perhaps never end.")

www150.statcan.gc.caThe Daily — Experiences of Canadians with long-term symptoms following COVID-19As of June 2023, the majority of Canadians had been infected by the virus causing COVID-19. Most people recover from their symptoms and are able to carry on with their lives, however, for many others, symptoms persist for months, often impacting their ability to work and their quality of life overall.
#CovidIsNotOver#LongCOVID#SARS2
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I thought I'd read "just one more paper" (uh huuuh 😏) tonight

Semi-randomly landed on nature.com/articles/s41591-021 from 2021

...huh

"The simplest solution to this is for social-media companies to remove the anti-vaxx misinformation superspreaders: the professional propagandists making a living from the anti-vaxx industry, from their platforms, as detailed in our July 2020 report. There is no moral justification for profiting from harmful lies, and there is no legal barrier to social-media companies’ removing them for breach of their terms of service. In fact, in the USA, moderation decisions are explicitly protected by law. The problem has never been ability; instead, it has been the will to act. Tech companies have failed to act because their business model relies upon keeping users on their platforms scrolling through content interspersed with advertising, regardless of that content’s impact on society. Their failure to act should be punished with tough government regulation." 💥

and that closing paragraph: "All of us have been doing our bit in 2020 and 2021 to contain the COVID-19 pandemic. Think of the friends and family you have not seen. Think of the medics risking their own lives and losing patients to this cruel virus. Think of the Herculean efforts made by scientists to develop a vaccine in record time. The anti-vaxx industry and technology companies, however, for their own solipsistic reasons, threaten to derail all that progress. It is up to all of us to stop them from doing so."

NatureDismantling the anti-vaxx industry - Nature MedicineInvestigations show that those spreading misinformation that undermines the rollout of vaccines against COVID-19 are well financed, determined and disciplined. To counter their activities, we need to understand them as an industry actively working to sow doubts about the deadliness of COVID-19, vaccines and medical professionals’ integrity.
#CovidCompetent#CovidIsNotOver#COVID
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This guy was handling a puking kid 2 days ago, and now is refusing to cover his sneezes at all. Offered an N95; not well received. "It's just dusty in here." Ok but N95s filter dust too; also not well received.

I do not like parts of this timeline.

Anyways here's hoping 🎰 the HEPA and elasto 😷 suffice. I'd rather have more layers of 🧀 swiss cheese en.wikipedia.org/wiki/Swiss_ch now - and every time, but kinda feeling it now!

🤞 hope ocular protection 🥽 isn't needed for whatever this is

at least he's not sneezing directly on me but I've seen the infrared videos of aerosol dispersal 😦

en.wikipedia.orgSwiss cheese model - Wikipedia
#CovidCompetent#CovidIsNotOver#cleanAir
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