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#covidpapers

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Lorraine

Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link

mdpi.com/2076-0817/13/12/1070

my new edited🧵listing all the important papers that have come out over the past 4 years

actually understood >90% of this thanks to a couple books & lectures prior to reading

every abstract starts the same.. in 2019 SARSCov2 first appeared…
you do not want cancer in any form, yet so many pathways via Covid #ace2 #CovidPapers published December 6, 2024

MDPIEquivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a LinkThe COVID-19 infection caused by SARS-CoV-2 in late 2019 posed unprecedented global health challenges of massive proportions. The persistent effects of COVID-19 have become a subject of significant concern amongst the medical and scientific community. This article aims to explore the probability of a link between the COVID-19 infection and the risk of lung cancer development. First, this article reports that SARS-CoV-2 induces severe inflammatory response and cellular stress, potentially leading to tumorigenesis through common pathways between SARS-CoV-2 infection and cancer. These pathways include the JAK/STAT3 pathway which is activated after the initiation of cytokine storm following SARS-CoV-2 infection. This pathway is involved in cellular proliferation, differentiation, and immune homeostasis. The JAK/STAT3 pathway is also hyperactivated in lung cancer which serves as a link thereof. It predisposes patients to lung cancer through myriad molecular mechanisms such as DNA damage, genomic instability, and cell cycle dysregulation. Another probable pathway to tumorigenesis is based on the possibility of an oncogenic nature of SARS-CoV-2 through hijacking the p53 protein, leading to cell oxidative stress and interfering with the DNA repair mechanisms. Finally, this article highlights the overexpression of the SLC22A18 gene in lung cancer. This gene can be overexpressed by the ZEB1 transcription factor, which was found to be highly expressed during COVID-19 infection.
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Lorraine

I really do not understand people.
Their complete lack of empathy for others & imagination

Did they not read enough as children? Are they delusional enough to think they are health superior & nothing will ever happen to them?

Getting Covid over & over has become a rite of passage.. something to commiserate over, to bond over🙄 then to laugh off

It was a giant mistake not to link #sarscov2 #viralPersistence #reinfection with #HIV

Complex stuff bores people so a clickbait statement is required

I will patiently wait for the #science #covidPapers to come out, & keeping in mind I’ve never even taken basic biology, but after observing this disease in myself & my spouse then peering out at an endless supply of people constantly exposing themselves…

have concluded that “clearing” remnants of virus to very low levels is key to long term survival

Not clearing it accelerates aging & all the fun diseases that come w/old age

We aren’t seeing it in large numbers in <30 years old, but that’s because they started w/a newer “car” & their endothelium hasn’t been wrecked as much by lifestyle

So it’s going to pick off the older & more vulnerable, then work its way down the age bracket

I know I’m right, but will patiently wait for the studies or the results I suppose

But all of this could be prevented by #wearADamnMask

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Lorraine

archive.is/2024.02.27-033708/h

The scientists don’t seem very puzzled if you read the entire article. There’s caution around correlation & causation, but sometimes things are just obvious. Oh, & the endless science #covidPapers

If Bay Area woman died Feb 6… & I caught it in NYC by March 23… add in incubation time plus my Dr went down a week before…one could trace the speed of spread. Also in 2020 not every person was contagious

It’s so much worse in 2024..

Disease vectors everywhichwhere🙄 Good times🙄🙄

Screenshot of Bloomberg article Pic of ER nurse wearing Aura mask standing over what looks like an intubated patient. View is blocked by medical equipment
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Lorraine

Uhhhhh. Hmmmm. Who’s going to tell them?

Not me.

The comments are wild.

They’re never going to put 2 + 2 together. Like literally never.

It doesn’t matter how much science or #CovidPapers you give them on a silver platter, they will believe the most insanest theories vs the logical one

Honestly think people were smarter during the Dark Ages given what they had to work with🤦🏻‍♀️

A screenshot of tweet about collective bizarre menstrual issues SAM ₴ O @soulmuva I feel like February has been messing with a lot of people's menstrual cycles - whether yours is late or early, you're experiencing the symptoms but no actual period, or the symptoms are more intense. 12:28 PM • 2/20/24 • 1.3M Views 2,598 Retweets 1,795 Quotes 19.6K Likes 2,355 Bookmarks 17 SAM A © @soulmuva • 7h Collectively, it feels like this is rooted in the emotions and the stress a lot of us are experiencing - people are harboring their emotions and are experiencing imbalances. The world is imbalanced = our bodies are imbalanced. We're all collectively experiencing it in how spirit... Show more
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Lorraine

@jeffjarvis zeroes.ca/@Lorrrraaaaine/11158
We live in a stupid society.
People believe it’s about “protecting other people” but it’s also VERY much about protecting yourself

Media doesn’t cover the hundreds of #covidPapers that SCIENTIFICALLY prove long term harm

“Vulnerable” are ALL of us & it will be at everyone’s peril to not realize this is so

#wearARespirator b/c #masksAreAmazing & they work when worn properly AND PROTECT YOU FROM #airborneVirus

There’s more than #covid19 around..

zeroes.caLorraine (@Lorrrraaaaine@zeroes.ca)Attached: 1 image https://youtu.be/nLHdbGZtkj8 Here’s the video again #covidPSA #Northwestern #winterIsHere #aerosols build up in the air, especially in enclosed spaces & if there is no ventilation it can linger for hours depending on #relativeHumidity & temperature Just because a C02 monitor appears low or the room is empty doesn’t mean there isn’t Covid lingering You just need 1 second under the right circumstances to inhale enough virus to make it replicate inside you There’s nothing called “too cautious” these days🖤🖤 Also… how has this video ONLY had 4133 views🤦🏻‍♀️
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Lorraine

Study: Sperm counts decline even after mild #COVID infections | CIDRAP

cidrap.umn.edu/covid-19/study-

If you want to make any men of ANY age uncomfortable, or freak out any women that really want to have children.. this is the article to send them

It’s a small study of only 45 men but it is still ongoing #fertility #testosterone #covidPapers

CIDRAPStudy: Sperm counts decline even after mild COVID infections
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Lorraine

easychair.info/p/the-intrinsic

This piece by @fitterhappierAJ makes the cut in my Covid 2024 edit
It ONLY came to my attention the other day (b/c I don’t much venture out of my eco-system of truth) exactly HOW bad the advice in traditionally searched “health” media is & it appears to have started in earnest approx 1 year ago

This isn’t ground zero, but in this article common sense of Dr. Ziyad Al-Aly is counterpointed w/: But Dr Celine Gounder, an infectious disease epidemiologist and editor-at-large at Kaiser Health News, is among those who said that #immunity from a first infection means that a subsequent infection poses a lower risk of such outcomes.

“There is nothing about a #reinfection that is more dangerous than an original infection, and if anything, a reinfection is going to be lower risk because you have some immunity baseline at the time of reinfection,” said Gounder.

theguardian.com/world/2023/jan

What a difference a year of #misinformation #disinformation makes b/c this EXACT narrative permeates the worldwide collective consciousness. It is AMAZING this is taken as fact at this point as it is a COMPLETE LIE!

If anyone has any specific #tcell #bcell #CovidPapers or articles that reference them that would be useful in countering this narrative, please post here🙏🏼🖤🖤🖤

Perhaps we can be in a different place in 1 year…🌈🌈

People CAN be persuaded w/logic/facts & if they are experiencing symptoms & seeing it all around them, all the more

Easy Chair · The Intrinsic Severity of SARS Cov 2By Anthony J Leonardi, MBBS, PhD
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Lorraine

“Why did genetics gain a bigger role as the pandemic progressed?”

“But as people became infected and vaccinated, those environmental factors became more homogenized, and genetic factors related to people's different immune responses began to emerge as the more prominent driver of who got infected and to what extent.”

🤔… environmental factors you say became more homogenized TO A VIRUS THAT HAS ZERO F€£%ING DURABLE IMMUNITY?

See, I myself in Summer 2022 had questions as to WHY people who had gone along w/NYC dropping indoor mask mandate in Spring 2022 &🚫😷in forward facing jobs weren’t getting sick. It actually became my obsession during that period of time

Oh then BA5 appeared in July 2022 that I nearly caught & me who has <0 science background was trying to figure out wtf was happening b/c I REALLY was trying to avoid this like The Plague

And genes… that special 1% gene Everyone thought they had. My spouse ACTUALLY has it & I got to see it in action 2020 & 2021 & 2022. Took me 2 years to figure out he & his family had it but for my own safety & his, I forced him to bubble 99.88% of the time b/c I didn’t think untrammeled exposure would hold up & I was correct. His family is not doing well. Whatever “protective” gene they had, it’s broken & doesn’t work anymore. Probably because 2021 virus isn’t 2024 Covid

I’m not clear on 30%-70% genetics they’re referring to as being protective or more susceptible but it doesn’t matter b/c the guy doing the study even says “it’s not an exact science”. Oh really🙄w/ a 40 point range I’m so surprised🙄

They keep talking about “to what extent” as in severity of virus… are they living under a🪨rock? #asymptomatic HELLO! And there’s COUNTLESS #CovidPapers going on about how a mild infection is as if not more dangerous than a symptomatic one🤦🏻‍♀️

TIME SUBSCRIBE Why did genetics gain a bigger role as the pandemic progressed? At the beginning of the outbreak, public health measures such as mask mandates, lockdowns, and isolation practices had a bigger influence on who got infected, since nearly everyone was encountering SARS- CoV-2 for the first time and had little immunity to fend off the virus. But as people became infected and vaccinated, those environmental factors became more homogenized, and genetic factors related to people's different immune responses began to emerge as the more prominent driver of who got infected and to what extent. It's not an exact science, but Tatonetti says this type of modeling can help public health experts understand when interventions like masks are most impactful. And it seems to be at the start of outbreaks. "These results show that public health practices really do matter, and they worked," he says. That's important to remember, since genetic factors are out of our control-while behavior changes can help us tip the balance, at least somewhat, in our favor.
TIME SUBSCRIBE At the beginning of the study, the researchers estimated that genetics accounted for about 33% of a person's likelihood of getting infected, while by the end, genetics accounted for 70%. That's a huge jump from previous studies, which estimated that a person's genes only explained about 1% of their likelihood of infection. This indicates that more genes are likely contributing than previously thought. "We don't know what the specific genetic variants are yet, but we do know there are other genetic variants that confer some sort of susceptibility, which might explain why some people are reinfected multiple times and others seem resistant even if they are family members living together,» says Nicholas Tatonetti, associate professor of computational biomedicine at Cedars-Sinai and senior author of the
@ nature.com Download PDF returned to normal routines. Additionally overall access to risk mitigating factors such as high-quality masks and testing increased. These changes likely reduced inter-patient differences in shared environment. This homogenization of risk would naturally inflate the importance of genetic differences between the families. The genetic pools of our case and control groups also likely changed in meaningful ways. Patients with protective alleles may have accounted for a higher proportion of our control group over time as patients with risk and neutral alleles were infected and moved to the case group. Lastly, we expect any genetic factors affecting COVID-19 vaccine efficacy to impact our estimates with their introduction partway through our study. To our knowledge no other study has examined the change in heritability and
Download PDF by Killingley et al. found that only 53% of their subjects directly exposed to SARS- CoV-2 developed COVID-19. While the authors were unable to determine why some patients did not develop COVID-19, they speculated that they may have cross re-reactive immune cells that provided protection20. We would expect that patient-specific, risk mitigating factors should become easier to identify as the pandemic progresses and patients that lack these factors are infected. Whether these differences are due to genetic variation, use or response to vaccines, or variation in immune cell population is difficult to untangle. If these differences are more likely to follow family-lines, we would expect the variation to be attributed to heritability in our study, which could inflate our heritability estimates.
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Lorraine

papers.ssrn.com/sol3/papers.cf

There are STILL no good news #covidPapers #prePrint yet🙄

2024 is the year I get ALL the evidence to back up everything I’ve been thinking & harping about for nearly 2 years

this is an atrocious catastrophe & despite all the CLEAR & OBVIOUS evidence, there will be no change in behavior

Everyone’s apparently chosen their team.. made their bed🛏️so to speak

Not being able to pivot can literally kill you these days🤷🏻‍♀️ #dementia

Quick synopsis of attached study pre-print
Synopsis of tweets Outbreak Updates @outbreakup... 19h Women stand on the frontline of this emerging crisis, disproportionately bearing the brunt of this cognitive degradation. This alone should be a major headline. 5/ 91 17 10 © 69 I. 1,297 Outbreak Updates @outbreakup... 19h Beyond the acute battle with the virus lies a prolonged war against its long-term effects on our society. A silent epidemic of dementia is around the corner. 6/ © 2 178 © 63 1 1,208 Outbreak Updates @outbreakup... 19h As SARS-CoV-2 reveals its long game, it's clear: We're not just fighting for recovery. We're fighting to prevent a wave of cognitive catastrophe.
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Lorraine

nature.com/articles/s41467-023
@drclairetaylor
Has a long🧵explainer on this, but this is the muscle exercise #CovidPapers was referring to earlier

I’m not adverse to financial budgets in my personal life & find it similar to energy budgets in regards to #longCovid #pasc

#pacing is🗝️to not having more adverse after effects of #acuteCovid but it’s something one needs to know the existence of in order to implement it

YET the health gurus insist you must get back on the🐎& power through it

Results will be devastating

NatureMuscle abnormalities worsen after post-exertional malaise in long COVID - Nature CommunicationsIn this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic metabolic disturbances and infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID.
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Lorraine

longcovid.physio/long-covid-vi
It’s Day 17 for me but Day 16, yesterday, noticed although I can do more than forced physical rest (is it really resting if you’re still engaging your mind though? b/c you refuse to meditate & you can’t sleep?) my physical limitations definitely exist

All I did was a bit of vacuuming in AM & drafted a simple pocket pattern on floor in the afternoon & was absolutely knackered

The #sarscov2 #CovidPapers about muscles recently making rounds makes total sense & I TAKE RESTING SERIOUSLY yet still…

This video might be helpful #pasc #longCovid

Andy Warhol vacuuming Basically me except I use even shorter attachment because I’m ocd about dust
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Lorraine

The great thing about high profile moron “experts” making blithe uninformed comments such as “Covid doesn’t really damage the immune system” is it angers people who ACTUALLY know & they come at them with #CovidPapers #Jha

This will be my continuing🧵on anything related to the destruction of #tcells #bcells #ImmuneDysregulation in an attempt to be organized if only for myself🖤

Published January 14, 2022
bmcmedicine.biomedcentral.com/

In truth just skimmed but my grasp on this in January 2024 is something that would have been impossible for me to understand in 2022 while experiencing my #sarscov2 2nd infection b/c my level of biology was zero & my lack of understanding led me to believe #hybridImmunity would give me 2 years at least. Mind you I never took my mask off except w/my MIL🦃🎄2021

Philip Dettmer “immune” book along w/the incredibly intelligent🧠🧠🧠here🐘&🐦have been invaluable in at least allowing me to read & generally follow along

Basically this study tells me, stay down for 6 months minimum

BioMed CentralLong-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC MedicineBackground Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms for many months after infection, a condition referred to as “long COVID”, post-acute sequelae of COVID-19 (PASC), post-acute COVID-19 syndrome, or post COVID-19 condition. However, despite the plethora of research on COVID-19, relatively little is known about the molecular underpinnings of these long-term effects. Methods We have undertaken an integrated analysis of immune responses in blood at a transcriptional, cellular, and serological level at 12, 16, and 24 weeks post-infection (wpi) in 69 patients recovering from mild, moderate, severe, or critical COVID-19 in comparison to healthy uninfected controls. Twenty-one of these patients were referred to a long COVID clinic and > 50% reported ongoing symptoms more than 6 months post-infection. Results Anti-Spike and anti-RBD IgG responses were largely stable up to 24 wpi and correlated with disease severity. Deep immunophenotyping revealed significant differences in multiple innate (NK cells, LD neutrophils, CXCR3+ monocytes) and adaptive immune populations (T helper, T follicular helper, and regulatory T cells) in convalescent individuals compared to healthy controls, which were most strongly evident at 12 and 16 wpi. RNA sequencing revealed significant perturbations to gene expression in COVID-19 convalescents until at least 6 months post-infection. We also uncovered significant differences in the transcriptome at 24 wpi of convalescents who were referred to a long COVID clinic compared to those who were not. Conclusions Variation in the rate of recovery from infection at a cellular and transcriptional level may explain the persistence of symptoms associated with long COVID in some individuals.
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Lorraine

it took me several check outs from the library to get through this, but it is one of the most interesting, depressing & dense books I’ve ever listened to & am a better person for listening to it altho👀👀👀

After reading/skimming the peer reviewed #CovidPapers all of 2022 & noticing #acceleratedAging all around me for the past year, learning about #dementia was my goal for 2023 & boy did #TiaPowell #DementiaReimagined deliver

Having never known about it, what I can say is, you definitely do not want this; it makes #cancer look like a🎄🎁

Book was published in 2019 when there were 75 million #babyBoomers were approaching the prime dementia ages where 30-50% will have it by age 85. Post Covid tho, that number has risen %-wise & age of onset lowered by DECADES

Symptoms aren’t straight forward b/c it’s not merely the stereotypical memory loss & I realized one of my building neighbors had been suffering from it for at least 15 years after listening to all the presentations of different types. There are 7 stages & you could probably hide the fact you have it w/out too much difficulty #brainFog

There is no cure & the “recommendations of prevention” are honestly… useless if you don’t remember the first rule; DO NOT GET COVID/viruses or minimize the amount of times you do & certainly don’t breathe air arbitrarily🚫😷

Never thought about dementia b/c it didn’t run in my family but after 2 full infections, now I worry just a bit. Ok.. I’m a fatalist hypochondriac so perhaps slightly more than a “bit” but medical paranoia has been generally my friend, so I’ll continue being paranoid

The stories are harrowing but this book is definitely what I needed to know b/c mental decline will only be ever increasing all around as more time goes by

Book Cover of a book about Dementia by Tia Powell published in 2019 < Back 9:50:04 (15 4 78m 9:49:00 § 88% -1:18:55 DEMENTIA Reimagined Building a Life of Joy and Dignity from Beginning to End Tia Powell, MD Director o the MONTEFIORE EINSTEIN CENTER FOR BIOETHICS Chapter 11 TABLE OF CONTENTS 18m » 9:50:00 9:51:00
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Lorraine

@jessicawildfire
this is truly a #phenomenal #resource

This section has 35 great links #threads #CovidPapers about #TCells #immuneSystem

Many I’ve seen before, but to have it organized in one place is #priceless #gold

#airborneAIDS is extremely controversial, but think it’s apt

Can understand the anxiety of not wanting to accept #reinfection or infection of #SARS2 is fatal but it’s sheer stupidity to ignore🐘

This is why nobody likes me, & you know what, I really don’t care🖤🖤

@ jessicawildfire.substack.com You can see the research here. So why is everyone still getting sick so often? Covid basically turns your immune system upside down. For some people, it causes dysregulation. In others, it causes lasting damage. Studies have found that Covid overstimulates your T cells and causes them to burn out. They've also found that Covid attacks and disables several other types of immune cells. It even leaves an imprint or "backdoor" for future variants. It's unsettling, but some researchers have drawn comparisons between Covid and HIV in terms of its immune damage. You can see the research here. Don't vaccines protect against severe illness? Studies on vaccine effectiveness have confirmed that boosters are waning faster, providing anywhere from 50-70 percent effectiveness against severe disease, and even
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Lorraine

nitter.pussthecat.org/tactnowi
@TACTNowinfo 22 links to #CovidPapers #telomere #ImmuneDysfunction
Haven’t seen the sun since 1989, especially w/out sunblock but I’m relatively ambivalent about #aging

Def more concerned about internal aging,which as a perk, affects the outside
It could be my imagination,but as a fine art artist, we naturally look at minutiae of details #wrinkles & I swear people are #prematureAging like Bowie The Hunger
White/grey hair is a visible sign of #telomereShortening #FYI

NitterTACT (@TactNowInfo)April 19, 2022 Indirectly related to immune system. “We also find increasing acceleration of epigenetic aging and telomere attrition in the sequential blood samples from healthy individuals and infected patients." https://www.nature.com/articles/s41467-022-29801-8?s=09
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Lorraine

soooooooooo… uhmmmmm.. er
Listen, I get it, the peer pressure & still love the Oscar gown & matching overlay face mask but this is not how an #airborne virus works…
What’s the solution I keep getting asked as I repeat the same answers

Nobody wants to hear & truly wish I were wrong, but if you’ve ever witnessed death from a debilitating disease..most rational people will want to avoid that #fate

read far too many #science #CovidPapers follow talented smart people #thisIsNotaDrill #reinfection

Photo of Jessica Chastain at the 2023 Golden Globe awards sitting down at her table sans gorgeous face mask
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