Lingolol

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ETIDIoH#Usutu virus African 3.1 #lineage, <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/portugal/" target="_blank">#Portugal</a>, 2021-2023Source: BioRxIV, <a href="https://www.biorxiv.org/content/10.1101/2024.12.04.626753v1?rss=1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2024.12.04.626753v1?rss=1</a> AbstractBackground: Usutu virus (Orthoflavivirus usutuense, USUV), a neurotropic arthropod-borne RNA virus of the family Flaviviridae, is a zoonotic virus that has spread throughout the European continent over the last three decades, since its emergence in Italy in 1996. However, no cases of USUV have been reported in Portugal so far. Material and methods: In the scope of an active surveillance program for Orthoflavivirus, we collected growing feather samples from 249 red-legged partridges (Alectoris rufa) hunted in southern Portugal during the 2021-2023 hunting seasons. Samples positive for USUV were subjected to whole genome sequencing and strain characterization. Results: Two partridges tested positive for USUV. Phylogenetic analyses of whole and partial genomes assigned the USUV strains to the African 3 lineage, specifically the African 3.1 sub-lineage.Conclusions: Our study confirms, for the first time, the circulation of USUV in wild birds in Portugal. Active surveillance of hunted partridges proved to be a useful, accessible, and cost-effective method for USUV monitoring, further supporting their value as effective sentinels for Orthoflavivirus surveillance. Given the ongoing circulation of USUV and the increasing risk of its spillover to other domestic and wild animals, and humans, additional efforts are needed to improve virus surveillance in Portugal from a One Health perspective.____<a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/arbovirus/" target="_blank">#ARBOVIRUS</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/flavivirus/" target="_blank">#FLAVIVIRUS</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/portugal/" target="_blank">#PORTUGAL</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/usutu-virus/" target="_blank">#USUTUVIRUS</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/wild-birds/" target="_blank">#WILDBIRDS</a>

Eric Pyrrhus4/11 Now, many RNA viruses have a viral protein called a <a href="https://mstdn.science/tags/viroporin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#viroporin</a>, which creates pores in membranes such as the endoplasmic reticulum.In some viruses, such as an <a href="https://mstdn.science/tags/enterovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#enterovirus</a>, the viroporin is well-known. (2B protein)In other viruses, the viroporin is better known for something else, as the viroporin function is not well appreciated.For example, in a <a href="https://mstdn.science/tags/flavivirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#flavivirus</a>, the NS2A protein is known as a capsid-assembly protein. Its function as a viroporin is less well-known.<a href="https://doi.org/10.1080/21505594.2017.1356540" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1080/21505594.2017.1356540</a>

Marco Radi-Time for a short <a href="https://qoto.org/tags/Introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Introduction</a>-I am a group leader in <a href="https://qoto.org/tags/MedicinalChemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MedicinalChemistry</a> at the University of Parma. My lab combines <a href="https://qoto.org/tags/chemical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chemical</a> & <a href="https://qoto.org/tags/computational" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#computational</a> techniques to develop novel pharmacological tools to study different Chronic Diseases (<a href="https://qoto.org/tags/CysticFibrosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CysticFibrosis</a>, <a href="https://qoto.org/tags/IBD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IBD</a>, <a href="https://qoto.org/tags/Hypercholesterolemia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Hypercholesterolemia</a>, <a href="https://qoto.org/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alzheimer</a>, <a href="https://qoto.org/tags/Cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cancer</a>) and Infective Agents (<a href="https://qoto.org/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARSCoV2</a>, <a href="https://qoto.org/tags/Enterovirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Enterovirus</a>, <a href="https://qoto.org/tags/Flavivirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Flavivirus</a>, <a href="https://qoto.org/tags/Monkeypox" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Monkeypox</a>, <a href="https://qoto.org/tags/HIV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HIV</a>). We are particularly interested in the development of <a href="https://qoto.org/tags/MultiTarget" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MultiTarget</a> inhibitors and open to new <a href="https://qoto.org/tags/collaborations" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#collaborations</a> in <a href="https://qoto.org/tags/DrugDiscovery" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DrugDiscovery</a>. <a href="https://qoto.org/tags/Tooting" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tooting</a> (sooner or later) about the <a href="https://qoto.org/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chemistry</a> and <a href="https://qoto.org/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a>

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