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#heterogeneity

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A Comprehensive Framework For Evaluating The Quality Of Street View Imagery
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doi.org/10.1016/j.jag.2022.103 <-- shared paper
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“HIGHLIGHTS
• [They] propose the first comprehensive quality framework for street view imagery.
• Framework comprises 48 quality elements and may be applied to other image datasets.
• [They] implement partial evaluation for data in 9 cities, exposing varying quality.
• The implementation is released open-source and can be applied to other locations.
• [They] provide an overdue definition of street view imagery..."
#GIS #spatial #mapping #streetlevelimagery #Crowdsourcing #QualityAssessmentFramework #Heterogeneity #imagery #dataquality #metrics #QA #urban #cities #remotesensing #spatialanalysis #StreetView #Google #Mapillary #KartaView #commercial #crowsourced #opendata #consistency #standards #specifications #metadata #accuracy #precision #spatiotemporal #terrestrial #assessment

Are you interested in cell #heterogeneity ? Would you like to work on understanding how single, heterogeneous cells work together to generate coordinated population responses using a mix of bioinformatics, wet-lab experiments and mathematical modelling?

Then come and do a PhD with us in sunny* Edinburgh!

ed.ac.uk/biomedical-sciences/p

This PhD programme will also enable you to develop your #teaching skills by participating in teaching activities at our joint institute in Haining, China to eventually work towards a fellowship from the Higher Education Academy!

Any questions just drop me a message and I'll be happy to clarify any doubts!

*well, today at least

The University of EdinburghFully funded 4 Year PhD studentships in Biomedical SciencesApplications are invited from outstanding students wishing to pursue a 4 Year PhD studentship in Biomedical Sciences from September 2024.

New #SystematicReview suggests that less efficient early auditory processing is a shared mechanism underlying both #LearningDisorders and #DevLangDis‬⁩ #DLD #heterogeneity
nature.com/articles/s41598-022

NatureAuditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis - Scientific ReportsAlthough learning disorders (LD) and developmental language disorder (DLD) can be linked to overlapping psychological and behavioral deficits, such as phonological, morphological, orthographic, semantic, and syntactic deficits, as well as academic (e.g., reading) difficulties, they are currently separate diagnoses in the DSM-5 with explicit phenotypic differences. At a neural level, it is yet to be determined to what extent they have overlapping or distinct signatures. The identification of such neural markers/endophenotypes could be important for the development of physiological diagnostic tools, as well as an understanding of disorders across different dimensions, as recommended by the Research Domain Criteria Initiative (RDoC). The current systematic review and meta-analysis examined whether the two disorders can be differentiated based on the auditory brainstem response (ABR). Even though both diagnoses require hearing problems to be ruled out, a number of articles have demonstrated associations of these disorders with the auditory brainstem response. We demonstrated that both LD and DLD are associated with longer latencies in ABR Waves III, V, and A, as well as reduced amplitude in Waves V and A. However, multilevel subgroup analyses revealed that LD and DLD do not significantly differ for any of these ABR waves. Results suggest that less efficient early auditory processing is a shared mechanism underlying both LD and DLD.

#Introduction Hi folks, I am an incoming group leader the the Francis Crick Institute in London. My group will combine #MathematicalModels and #MachineLearning to learn how regulatory rules emerge from #ProteinStructure and how they govern #heterogeneity in dynamic cell responses.

If that sounds interesting and you are currently looking for a PostDoc position - we are hiring! crick.wd3.myworkdayjobs.com/Ex

crick.wd3.myworkdayjobs.comPostdoctoral Training Fellow in Computational Biology – Fröhlich labThe Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London. Salary for this Role: From £40,125 with benefits, subject to skills and experience. Job Title: Postdoctoral Training Fellow in Computational Biology – Fröhlich lab Reports to: James Turner Closing Date: 09/Dec/2022 23.59 GMT Job Description: Postdoctoral Training Fellow in Computational Biology – Fröhlich lab Reporting to: Fabian Fröhlich, Group Leader Contact term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment The Research Group The Fröhlich lab develops models to describe the dynamic behaviour of biological systems combining techniques from mathematical modelling and machine learning. We develop computational tools to build and train these models on experimental data and apply these tools to understand the regulatory principles that determine the dynamic response to external perturbations. More details about the group and our research interests can be found here: www.frohlichlab.com The successful candidate will join a growing, multi-disciplinary team of scientists with the opportunity to contribute own ideas and help shape the research profile of the lab. Research projects will be supported by a vibrant, multi-disciplinary scientific community at the Crick, with ample opportunities for internal and external collaborations. Moreover, the candidate will have access to state-of-the-art core facilities at the Crick, including the High-Performance-Computing platform, and rich structured career development and networking opportunities. The Role Several research directions are being pursued and the successful candidate will have the freedom to develop and undertake their own independent research projects within the scope of the lab’s interests. Topics include development of hybrid models that use machine learning methods to contextualize ordinary differential equation (ODE) models using (single-cell) omics and imaging data; and the development of neural-network-based coarse-graining of protein-structure-based models. The post holder will be responsible for: Leading and developing specific research projects Developing and maintaining computational tools for the contextualization of ODE models Applying methods to biological data and interpreting results Collaborating with national and international partners Presenting work at lab meetings as well as national and international meetings Publishing scientific results Assisting in training graduate students and other members of the laboratory Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Open; Collegial, in addition to the following: Essential PhD in a relevant field or in the final stages of PhD submission Good knowledge and experience in coding (Python/Julia/C or similar languages), mathematics and statistics Technical expertise in either mathematical modelling or machine learning An interest in applying computational methods to biological problems A demonstrated ability to generate and pursue independent research ideas Excellent communication skills, written and verbal as evidenced by publications, preprints and conference presentations Cross-disciplinary mindset, collaborative attitude and teamwork experience Dedication to reproducible research and open science Desirable Experience with high-performance computing Experience with ordinary differential equation models Experience with dimensionality reduction and deep learning methods Experience with working in interdisciplinary environments Experience in developing and maintaining scientific software About Us At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources. We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners. We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise. We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science. If you are interested in applying for this role, please apply via our website. The closing date for applications is 30/11/2022 at 23:59 GMT All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. If you require a visa to work in the UK we will help support your application should you be successful Find out what benefits the Crick has to offer: For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits Equality, Diversity & Inclusion: We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level. Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success. The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices. Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion