Biomarkers of progressive multiple sclerosis decrease following autologous hematopoietic stem cell transplantation
Biomarkers of progressive multiple sclerosis decrease following autologous hematopoietic stem cell transplantation
Dimethyl fumarate attenuates liver injury in a mouse model of cecal ligation and puncture by modulating inflammatory, angiogenic and pyroptotic pathways
Acidic Nanoparticles Prevent HIV Pre-Exposure Prophylaxis (PrEP)-Induced Oligodendrocyte Impairments by Restoring Lysosomal pH in Adolescent Models
SnRNA-seq Interprets Mechanisms by which Three Glial Cell Types Influence Myelin Regeneration in Adult Drug-Resistant Epilepsy-Related Cognitive Impairment
Perturbation response scanning of drug-target networks: Drug repurposing for multiple sclerosis
A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC
Fingolimod synergizes with anti-PD-1 radioimmunotherapy in an experimental multiple sclerosis model through enhanced lymph node retention and CD8+ T cell depletion
Early-Life Mild Traumatic Brain Injury Alters Neurodevelopment and Behavior in Mice
Short-term exposure to particulate matter triggers a selective alteration of plasma extracellular vesicle-packaged miRNAs in a mouse model of multiple sclerosis
People with Multiple Sclerosis (MS) are more vulnerable to the effects of particulate matter (PM) exposure. People primed to develop autoimmunity (AEA) respond differently to PM compared to healthy subjects.
Immunological Tolerance Induced by Nanoliposome with Autoantigenie Peptide and Artesunate to Inhibit Complement and Remodel Immune Balance for Multiple Sclerosis Treatment
Multiple sclerosis (MS) is. demyelinating autoimmune disease accompanied by immune disorders and complement over activation. MOG-ART-Lip is. combination of an auto-antigenic peptide and an immune-modulator.
The tumor-sentinel lymph node immuno-migratome reveals CCR7⁺ dendritic cells drive response to sequenced immunoradiotherapy
Ablation or broad radiation can eliminate the primary tumor response to immunotherapy. Lymphatic-sparing, tumor-directed radiotherapy followed by PD-1 inhibition achieves complete and durable tumor responses.
Assessing the relationship of gut microbiota with neurological, psychiatric, and neurodegenerative disorders: a narrative review
Gut-brain axis is. bidirectional communication network regulated by the immune, nervous, and endocrine systems, microbial metabolites, and environmental factors such as diet, stress, circadian rhythm, and drugs/chemicals. The existing evidence consistently links ...
Assessment of the impact of interferon-ss and rituximab on NLRP3 and AIM2 expression and IL-1beta levels in patients with multiple sclerosis
Inflammasomes, particularly NLRP3 and AIM2, have been implicated in MS pathogenesis. Interferon-β (IFN-β) and Rituximab (RTX) are treatment agents for relapsing-remitting MS, but their impact on inflammasome regulation remains unclear. This s ...
Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses
Oligodendrocytes (OLs) form the myelin sheath around neuronal axons for the saltatory conduction of action potentials. In the present study, they found that OL maturation deficiency in Myrf-CKO mice caused spontaneous epileptogenesis and resulted in death. They also found that ...
Bdnf and Ntrk2 functions promote but are not essential for spinal cord myelination in larval zebrafish
Myelin is. specialized membrane produced by oligodendroglial cells in the central nervous system. It wraps axons to enhance conduction velocity and maintain axon health. Neurotrophic growth factor Bdnf and its receptor Ntrk2 promote myelination in rodents.
Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease
Maladaptive integrated stress response (ISR) activation is observed in human diseases of the brain. Genetic mutations of eIF2B cause chronic pathway activation resulting in leukodystrophy. 2BAct, an eif2B activator, rescued lethality and significantly extended the lifespan of. severe model of the disease.
Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression
Higher intake of alpha-linolenic acid (ALA),. plant-derived omega-3 polyunsaturated fatty acid (PUFA), was associated with. lower risk of multiple sclerosis in. prospective cohort study. The study followed 468 participants for. years.
Carboxylic Acid Bioisosteres Boost Nurr1 Agonist Selectivity
Nurr1 is. neuronal ligand-activated transcription factor implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and multiple sclerosis. Vidofludimus-derived Nurr1 agonist lacking DHODH inhibitor potency was found to be effective.
Had coffee with a guy this morning, he mentioned os/2. Do you remember and know what that is?
Cortical and white matter T1w/T2w development proceed in concert during early infancy