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54 posts7 participants18 posts today

Assessing the relationship of gut microbiota with neurological, psychiatric, and neurodegenerative disorders: a narrative review

Gut-brain axis is. bidirectional communication network regulated by the immune, nervous, and endocrine systems, microbial metabolites, and environmental factors such as diet, stress, circadian rhythm, and drugs/chemicals. The existing evidence consistently links ...

gregory-ms.com/articles/298609/

Assessment of the impact of interferon-ss and rituximab on NLRP3 and AIM2 expression and IL-1beta levels in patients with multiple sclerosis

Inflammasomes, particularly NLRP3 and AIM2, have been implicated in MS pathogenesis. Interferon-β (IFN-β) and Rituximab (RTX) are treatment agents for relapsing-remitting MS, but their impact on inflammasome regulation remains unclear. This s ...

gregory-ms.com/articles/298612/

Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease

Maladaptive integrated stress response (ISR) activation is observed in human diseases of the brain. Genetic mutations of eIF2B cause chronic pathway activation resulting in leukodystrophy. 2BAct, an eif2B activator, rescued lethality and significantly extended the lifespan of. severe model of the disease.

gregory-ms.com/articles/298637/

Had coffee with a guy this morning, he mentioned os/2. Do you remember and know what that is?

#computing#os2#ibm