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#TCells

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Lorraine

abcnews.go.com/GMA/GMA3/video/
SO CLOSE!!!
They’re so close to getting it😩
It’s inflammation🙄
It’s only the vulnerable🙄

There’s no excuse for this level of stupidity. NONE.

Saw a Tern post about 🚘accidents, & having been in one pretty crazy Vin Diesel one myself tipped off by a fender bender I didn’t fix months earlier… that metaphor analogy is something people will have to learn the hard way apparently

You can’t un-ring bells
#turbocancer #tcells #ImmuneDysregulation
#CovidIsNotOver #wearARespirator

ABC NewsVideo 'Unusual' cancers emerged after the pandemic. Is COVID to blame?A new article found that aggressive, late-stage cancers have seen an uptick following the pandemic. Is COVID to blame? Dr. Darien Sutton explains.
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Lorraine

time.com/6265510/covid-19-weak
#time from March 27, 2023
about #tcells #vaccination #etc

Surprisingly complex for a mainstream media article..

I don’t think it’s my imagination & surely others have noticed too that the further we go along since 2020, the #sarscov2 #covid articles are getting less informative & for the most part useless in terms of information #EverythingIsNotFine

Time · Getting COVID-19 Could Weaken Your Immune SystemBy Alice Park
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Lorraine

The great thing about high profile moron “experts” making blithe uninformed comments such as “Covid doesn’t really damage the immune system” is it angers people who ACTUALLY know & they come at them with #CovidPapers #Jha

This will be my continuing🧵on anything related to the destruction of #tcells #bcells #ImmuneDysregulation in an attempt to be organized if only for myself🖤

Published January 14, 2022
bmcmedicine.biomedcentral.com/

In truth just skimmed but my grasp on this in January 2024 is something that would have been impossible for me to understand in 2022 while experiencing my #sarscov2 2nd infection b/c my level of biology was zero & my lack of understanding led me to believe #hybridImmunity would give me 2 years at least. Mind you I never took my mask off except w/my MIL🦃🎄2021

Philip Dettmer “immune” book along w/the incredibly intelligent🧠🧠🧠here🐘&🐦have been invaluable in at least allowing me to read & generally follow along

Basically this study tells me, stay down for 6 months minimum

BioMed CentralLong-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC MedicineBackground Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms for many months after infection, a condition referred to as “long COVID”, post-acute sequelae of COVID-19 (PASC), post-acute COVID-19 syndrome, or post COVID-19 condition. However, despite the plethora of research on COVID-19, relatively little is known about the molecular underpinnings of these long-term effects. Methods We have undertaken an integrated analysis of immune responses in blood at a transcriptional, cellular, and serological level at 12, 16, and 24 weeks post-infection (wpi) in 69 patients recovering from mild, moderate, severe, or critical COVID-19 in comparison to healthy uninfected controls. Twenty-one of these patients were referred to a long COVID clinic and > 50% reported ongoing symptoms more than 6 months post-infection. Results Anti-Spike and anti-RBD IgG responses were largely stable up to 24 wpi and correlated with disease severity. Deep immunophenotyping revealed significant differences in multiple innate (NK cells, LD neutrophils, CXCR3+ monocytes) and adaptive immune populations (T helper, T follicular helper, and regulatory T cells) in convalescent individuals compared to healthy controls, which were most strongly evident at 12 and 16 wpi. RNA sequencing revealed significant perturbations to gene expression in COVID-19 convalescents until at least 6 months post-infection. We also uncovered significant differences in the transcriptome at 24 wpi of convalescents who were referred to a long COVID clinic compared to those who were not. Conclusions Variation in the rate of recovery from infection at a cellular and transcriptional level may explain the persistence of symptoms associated with long COVID in some individuals.
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Lorraine

@thepoliticalcat
#eatOutToHelpOut
Psychopaths are in power
The way I personally differentiate between garden variety sociopaths & psychopaths is the willingness to kill w/disregard

They fear what happened to the economy in 2020-2021 will happen again

Short term gains is all anyone cares about

Psychopaths are really insecure yet they possess an amount of #hubris that’s other worldly & believe they are special & will somehow be unscathed. I was “blessed”(🙄) w/an insane family to observe, not formally educated in it

This article is obvi meant to placate fears of getting repeatedly sick & preys on people’s ignorance of immune system

I fell for vague articles like this early on talking abstractedly about #Bcells #Tcells etc

These charlatans are #gaslighting people to their deaths. The🚑🚒🚨🚨🚨#nyc have been constant again & expect it will maintain this level until spring

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Lorraine

Why #Covid is still flooring some people #bbc

bbc.com/news/health-67726685

#idiots #idiocy

how about talking about how it damages #tcells instead of dated info from some immunology book back from when you were in Med school🙄

it👏🏼is👏🏼called👏🏼a👏🏼novel👏🏼virus👏🏼… for a reason!!!

also reasoning of not vaccinating #xbb for those under 65 to lessen burden on #nhs … 😶…😶😶😶😶😶🤯

Do these people hear themselves?🤦🏻‍♀️
I’m not dumb, ditzy on occasion but I get things eventually, however I read & see things constantly that are making me second guess myself; maddening

Prof Openshaw said: "The #viruses circulating now are pretty distant immunologically from the original #virus which was used to make the early #vaccines, or which last infected them.
"A lot of people have very little immunity to the #Omicron viruses and their #variants ."

WTF #misinformation is this?!?!
THERE IS NO NOR HAS THERE EVER BEEN DURABLE IMMUNITY TO A VIRUS THAT HAS MUTATED MORE IN 3 YEARS THAN FLU IN 15+++++ YEARS even if you were just infected

I just cannot🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️🤦🏻‍♀️

BBC NewsWhy Covid is still flooring some peopleA lot of us know someone who has felt pretty rough with the most recent form of the virus.
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Auscandoc

“By analyzing a longitudinal cohort of individuals infected with #SARSCoV2 during the first wave of #pandemic infections, Cai et al. found that subsequent #vaccination against #COVID19 enhanced the frequency and functional qualities of #spike-specific #Tcells. Despite up-regulation of inhibitory receptors, spike-specific T cells produced more effector #cytokines and cytotoxic molecules after #vaccination” mstdn.social/@erictopol/111546

Mastodon 🐘Eric Topol (@erictopol@mstdn.social)Vaccination after Covid does not lead to T cell exhaustion—it invigorates T cell functionality https://www.science.org/doi/10.1126/sciimmunol.adh0687
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Lorraine

#NYC struggling to contain rising #tuberculosis cases - #POLITICO

politico.com/news/2023/10/04/t
“Together, with the emergence of #HIV, which suppresses the #immuneSystem and leaves people more vulnerable to active #TB infection, the disinvestment created a perfect storm for a resurgence.

By the early 1990s, New York City was the epicenter of a nationwide tuberculosis epidemic. The city spent $1 billion to expand its TB control program, staffing the bureau with over 600 people to treat well over 3,000 cases a year.”

Last year there were 536 cases..
Now technically TB despite being #airborne should be kind of difficult to catch. My friend & his business partner got it from working in the same small office w/a🇬🇧intern who he also smoked pot with. However if your immune system is decimated by say having low #tcells you’re far more susceptible

Those #antibiotics were surreal looking; giant huge pink pills➕➕& you had to take them for a long time

#AIDS wasn’t rampant in the general population in the 80’s & 90’s unlike #sarscov2 #winterIsComing

POLITICOTuberculosis cases are rising in New York. The city is struggling to keep up. Budget cuts and understaffing are delaying the city’s ability to handle an increase in tuberculosis patients.
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Benjamin Carr, Ph.D. 👨🏻‍💻🧬

A blood test for long #Covid is possible, new research suggests
The research is among the first to prove that "#LongCovid is, in fact, a biological illness," said David Putrino, principal investigator of the new study and a professor at the Icahn School of Medicine at Mount Sinai in New York. The activity of #immune system cells called #Tcells and #Bcells — which help fight off #germs — was "irregular" in long Covid patients, Putrino said.
nbcnews.com/health/health-news

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Victoria Stuart 🇨🇦 🏳️‍⚧️

CAR T cell immunotherapy strategy against all blood cancers
sciencedaily.com/releases/2023

* disambiguation/background: en.wikipedia.org/w/index.php?f
* broad new strategy holds hope for treating virtually all blood cancers with CAR T cell therapy
* currently approved for 5 subtypes of blood cancer
* potential efficacy demonstrated in preclinical study

Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy
science.org/doi/10.1126/scitra

ScienceDailyExpanding the impact of CAR T cell therapy: An immunotherapy strategy against all blood cancersA broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists have demonstrated the potential efficacy of this approach a preclinical study.
#cancer#Tcells#immunotherapy
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Jennifer Moore 😷

"...long-term immune system activation in several specific tissues ...SARS-CoV-2 RNA may persist in gut tissue for nearly 2 years after the initial infection. Overall, these observations challenge the paradigm that COVID-19 is a transient acute viral infection and provide evidence for T cell activation and viral persistence in tissues well beyond the initial illness."

medrxiv.org/content/10.1101/20

medRxiv · Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is growing evidence that viral persistence and immune dysregulation may play a major role. We performed whole-body positron emission tomography (PET) imaging in a cohort of 24 participants at time points ranging from 27 to 910 days following acute SARS-CoV-2 infection using a novel radiopharmaceutical agent, [18F]F-AraG, a highly selective tracer that allows for anatomical quantitation of activated T lymphocytes. Tracer uptake in the post-acute COVID group, which included those with and without Long COVID symptoms, was significantly higher compared to pre-pandemic controls in many anatomical regions, including the brain stem, spinal cord, bone marrow, nasopharyngeal and hilar lymphoid tissue, cardiopulmonary tissues, and gut wall. Although T cell activation tended to be higher in participants imaged closer to the time of the acute illness, tracer uptake was increased in participants imaged up to 2.5 years following SARS-CoV-2 infection. We observed that T cell activation in spinal cord and gut wall was associated with the presence of Long COVID symptoms. In addition, tracer uptake in lung tissue was higher in those with persistent pulmonary symptoms. Notably, increased T cell activation in these tissues was also observed in many individuals without Long COVID. Given the high [18F]F-AraG uptake detected in the gut, we obtained colorectal tissue for in situ hybridization SARS-CoV-2 RNA and immunohistochemical studies in a subset of participants with Long COVID symptoms. We identified cellular SARS-CoV-2 RNA in rectosigmoid lamina propria tissue in all these participants, ranging from 158 to 676 days following initial COVID-19 illness, suggesting that tissue viral persistence could be associated with long-term immunological perturbations. ### Competing Interest Statement MJP reports consulting fees for Gilead Sciences and AstraZeneca, outside the submitted work. TJH reports consulting fees for Roche and Regeneron outside the submitted work. ### Funding Statement PET-imaging and peripheral blood immune testing was supported by a Merck Investigator Studies Program Grant (to TJH). PET-imaging Gut biopsy collection and testing was supported by grants from the PolyBio Research Foundation (to TJH, HV and MJP). This work was also supported by NIH/National Institute of Allergy and Infectious Diseases grants (3R01AI141003-03S1, R01AI158013, K23AI157875, and K24AI145806); the Zuckerberg San Francisco General Hospital Department of Medicine and Division of HIV, Infectious Diseases, and Global Medicine. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This study was approved by the University of California, San Francisco Institutional Review Board. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors
#covid#research#LongCovid
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Victoria Stuart 🇨🇦 🏳️‍⚧️

Cancer Cloaking Device Revealed
cancer.columbia.edu/news/cance
Discussion: news.ycombinator.com/item?id=3

* Malignant melanoma (skin cancer) deploys elegant molecular mechanism to evade natural immune responses, therapies
* immune system eliminates abnormal cells; cancers can elude it
* tumor cells that suppressed cell surface protein CD58 expression better at escaping immune surveillance
* hinted at how melanomas might be hiding f. T cells
...

Herbert Irving Comprehensive Cancer Center (HICCC) - New YorkCancer’s Cloaking Device RevealedResearch from Dr. Ben Izar suggests new strategies for attacking malignant melanoma and possibly other types of cancer.
#cancer#melanoma#CD58
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Lorraine

@jessicawildfire
this is truly a #phenomenal #resource

This section has 35 great links #threads #CovidPapers about #TCells #immuneSystem

Many I’ve seen before, but to have it organized in one place is #priceless #gold

#airborneAIDS is extremely controversial, but think it’s apt

Can understand the anxiety of not wanting to accept #reinfection or infection of #SARS2 is fatal but it’s sheer stupidity to ignore🐘

This is why nobody likes me, & you know what, I really don’t care🖤🖤

@ jessicawildfire.substack.com You can see the research here. So why is everyone still getting sick so often? Covid basically turns your immune system upside down. For some people, it causes dysregulation. In others, it causes lasting damage. Studies have found that Covid overstimulates your T cells and causes them to burn out. They've also found that Covid attacks and disables several other types of immune cells. It even leaves an imprint or "backdoor" for future variants. It's unsettling, but some researchers have drawn comparisons between Covid and HIV in terms of its immune damage. You can see the research here. Don't vaccines protect against severe illness? Studies on vaccine effectiveness have confirmed that boosters are waning faster, providing anywhere from 50-70 percent effectiveness against severe disease, and even
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Jo-stands on guard, elbows up.

@Empathy1st
A general list of health benefits studied in Kefir
ncbi.nlm.nih.gov/pmc/articles/

Kefir and it's effects on immune system and T-cell proliferation & regulation. #COVID #tcell
frontiersin.org/articles/10.33

Kefir, Immune System and T-Cells
pubmed.ncbi.nlm.nih.gov/236217

PubMed Central (PMC)Analysis of Health Benefits Conferred by Lactobacillus Species from KefirLactobacilli are among the most common microorganisms found in kefir; a traditional fermented milk beverage produced locally in many locations around the world. Kefir has been associated with a wide range of purported health benefits; such as antimicrobial ...
#immunity#Kefir#probiotics
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