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#dopamine

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Alper<p>Nihuhahahahaha!</p><p>I think this 70 year old <a href="https://mas.to/tags/sewingmachine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sewingmachine</span></a> is the next best thing I acquired since my <a href="https://mas.to/tags/3dprinter" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>3dprinter</span></a>!</p><p>I just got enough <a href="https://mas.to/tags/dopamine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>dopamine</span></a> to start something and just <a href="https://mas.to/tags/sew" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sew</span></a> a case for my cup that I keep in deep dirty internals of my backpack from a leftover <a href="https://mas.to/tags/jeans" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>jeans</span></a> like <a href="https://mas.to/tags/fabric" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fabric</span></a>. My first asymmetric <a href="https://mas.to/tags/sewing" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>sewing</span></a> with round bottom and I aced it in the first try. With my signature friction know to hold it all together 😎</p><p>Just bend one needle in the process 👉👈<br><a href="https://mas.to/tags/diy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>diy</span></a></p>
Albert Cardona<p>"The dopaminergic system of Caenorhabditis elegans", Muralidhara and Hardege, 2025<br><a href="https://royalsocietypublishing.org/doi/10.1098/rsos.250843" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">royalsocietypublishing.org/doi</span><span class="invisible">/10.1098/rsos.250843</span></a></p><p>That's the review I was waiting for – finally I have the field laid out to write the reinterpretation of part of the worm's pharyngeal ring – aka the brain – as an antennal lobe and a mushroom body.</p><p><a href="https://mathstodon.xyz/tags/Celegans" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Celegans</span></a> <a href="https://mathstodon.xyz/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>neuroscience</span></a> <a href="https://mathstodon.xyz/tags/dopamine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>dopamine</span></a></p>
Court Cantrell prefers not to<p>If I get ambitious, I'll try to post images of some of my builds here. I only barely know how to take in-game screenshots &amp; have no idea how to get those from the Xbox to my phone. So it'll have to be pics taken of my TV screen. Yes, I still live in the 20th. I'm tired. I wanted to be happy --I got fascism, whadday'all want from me? 😉</p><p>So, that's the easy peasy <a href="https://mastodon.social/tags/dopamine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>dopamine</span></a> hits story. Its epilogue consists of how the easy hits are starting to leave me useless for a lot of regular life shit. </p><p>/5</p>
Coffeedate with ADHD<p>I am in this picture and I don't like it </p><p><a href="https://mastodon.social/tags/adhd" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>adhd</span></a> <a href="https://mastodon.social/tags/adhdmeme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>adhdmeme</span></a> <a href="https://mastodon.social/tags/comic" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>comic</span></a> <a href="https://mastodon.social/tags/dopamine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>dopamine</span></a> <a href="https://mastodon.social/tags/adhs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>adhs</span></a> <a href="https://mastodon.social/tags/tdah" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>tdah</span></a></p>

Impulsive-hyper ADHD overdrive 

A lot has happened in the last 2½ months, give or take a few days. Several surgeries, big painful trauma, a great loss causing huge grief… Dealing with all this, and trying to recover of it all, has been taking a lot of me. When you’re already dealing with a chronic illness, you have less spoons to deal with. And then, at some point, you’ve used all available spoons. You’ve used all the spoons that you tried to borrow from days in your future (if that makes sense). You are sad, close to depression, and tying to find a way to prevent that from happening.

My ADHD knows that there is something that gives me “easy dopamine”, a quick rush, a feeling of accomplishment, a short moment of happiness, of satisfying some long-craving needs… Unfortunately, it usually means that my bank account is suffering, and in the end, I am in trouble. I need to recognize it, to realize it, to acknowledge it and then… Fight it. And while I know I can do it, as I’ve done it before, I also know that during times like these, I am not always strong enough to overcome it fast enough.

[…]

cynnisblog.wordpress.com/2025/

Crossing the Blood Brain Barrier

"Reprocessing Episodic Memory", an addition to Project Restoration, and how I've been spending free time thinking about the brain.

> ... blasting the prefrontal cortex with supra-physiological dopamine levels ... blunt-force impact trauma ... boosting its metabolic precursor l-3,4-dihydroxyphenylalanine ...

- prose.winterschon.com/reproces

Prose · 🎁 Reprocessing Episodic Memory
More from Eva Winterschön
Replied in thread

@overholt Ah, you are ALSO a task management connosseur.

I make .
I obsessively curate my lists.
I even wrote my own list making tool because I got sick of all the existing ones (and fck Trello that's why)

Putting things on lists doesn't actually make them ; they sit there taunting me. However the effort of curating my lists gives me just enough to dust my hands going "mission accomplished".

_Uh, you gonna DO any of those?_
Pff. No, those lists are for _show_.

Continued thread

Answering a question from @Andrewpapale. fediscience.org/@Andrewpapale/

Yep! Dip in happens at the moment of , when the mouse realizes that it made a mistake of its own agency.

And looks different in mice that eventually learn to avoid the wait zone by deliberating in the offer zone (precommitment).

FediScience.orgAndrew Papale (@Andrewpapale@fediscience.org)@adredish@neuromatch.social dip during quitting consistent with internally genetated negative RPE?
Continued thread

If I can find a video, tv show or music videos, including fan edits, to watch then that solves it. Brain occupied, boosted. Posting to the actor blog helps too. Tumblr in general, also here and instagram, depending on my mood. Tumblr is fun for discovery. I haven’t read any but posts come onto my dashboard and they’re great fun. Batman, Superman, the kids and Alfred. I’m a bit lacking in context and quite who’s who, but I love to see it.

Replied in thread

@elduvelle_neuro @Andrewpapale
@BrianMSweis

As Andy Papale said, we have a bunch of papers with both rats and mice on the task. (The data is all in nature.com/articles/s42003-022, and publicly available.) Generally, we talk about similarities, but mice learn slower. Rats show the transition from wait zone to in the offer zone in a few days, while mice take a lot longer.

Another space where I think there have been rat and mouse comparisons (although I don't find any explicit comparisons) is in the place field stability literature. My memory is that Cliff Kentros had really cool data on () stability as a function of levels and task. (nature.com/articles/s42003-022) Rats tended to live on the high-DA (place cells are stable) side while mice tended to live on the low-DA (place cells are unstable) side. But both could be manipulated with tasks and (ant)agonists. I don't know if anyone explicitly looked at this.

NatureSunk cost sensitivity during change-of-mind decisions is informed by both the spent and remaining costs - Communications BiologyComputationally parallel ‘change-of-mind’ tasks in mice, rats and humans are analysed and demonstrate that sensitivity to sunk costs during re-evaluation depends on the awareness of time spent and remaining.

"A temporally restricted function of the dopamine receptor Dop1R2 during memory formation", Kaldun et al. 2025 (Sprecher lab).
elifesciences.org/articles/993

In Kenyon cells, "loss of dop1R2 from ab or a'b' block the ability of flies to display measurable forms of longer forms of memory"

In other words, a specific dopamine receptor is now associated with long-term memory in fruit flies, and its loss does not affect short-term memory.

eLifeA temporally restricted function of the dopamine receptor Dop1R2 during memory formationThe dopamine receptor Dop1R2 plays a crucial role in the formation of longer-lasting memories, while it is dispensable for short-term memories.

Position available: Post Doctoral Research Associate in Whole Organism Neuroscience – lab of Iris Hardege, University of Cambridge, UK.

Deadline for application: August 3rd, 2025.

"This BBSRC-funded project aims to understand the interplay between excitatory and inhibitory metabotropic and ionotropic dopamine receptors and how they contribute to the regulation of complex behaviours."

jobs.cam.ac.uk/job/51874/

www.jobs.cam.ac.ukPost Doctoral Research Associate in Whole Organism Neuroscience (Fixed Term) - Job Opportunities - University of CambridgePost Doctoral Research Associate in Whole Organism Neuroscience (Fixed Term) in the Department of Zoology at the University of Cambridge.