Triona<p>A question that comes up a bunch in trans circles, should I take progesterone and why?</p><p>Generally, I suggest people try it and see how it goes. While most people are interested because of potential effects on breast growth, it's actually it's mental health benefits that are the main reason I would suggest it.</p><p>Some of the main metabolites of progesterone are anxiolytics (ie have an anti anxiety effect) and they also improve your sleep quality. The do this by increasing the impact of GABA in your brain.</p><p>For dosage I would suggest 100mg at night with dinner and 100mg in the morning with breakfast. swallowed not boofed (ie not as a suppository). As it has a short half-life spacing out the dosing helps with maintaining levels, and this is a common dosage for cis menopausal women.</p><p>Taking it in the morning doesn't make you sleepy because your GABA is normally lower in the morning and higher at night, and so works stronger in the evening because of that.</p><p>Taking it with food is also a good idea because it increases the absorption and serum levels according to the studies that have been done.</p><p>HOWEVER For a small number of people can can do the reverse, and cause insomnia and irritability because of GABA dysfunction, these people will have similar issues with benzos. According to papers on benzos that have reverse reaction it is likely to be less than 1% of people. The effect will last less than 24 hours because of it's short half-life, stop taking it if you find yourself struggling to sleep instead of sleeping better.</p><p>This is ignoring all the other stuff it does like other changes to neurotransmitters, reduction inflammation immune reactions, stronger bones, potential breast growth. Where we are less clear exactly on the details of how important these things are for trans people or how much progesterone is needed for them.</p><p><a href="https://cathode.church/tags/trans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>trans</span></a> <a href="https://cathode.church/tags/hrt" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>hrt</span></a> <a href="https://cathode.church/tags/transhrt" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>transhrt</span></a></p>